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Long-Term Growth Hormone Therapy Changes the Natural History of Body
Composition and Motor Function in Children with Prader-Willi Syndrome
Aaron L. Carrel, Susan E. Myers, Barbara Y. Whitman, Jens Eickhoff and David
B. Allen, Department of Pediatrics, University of Wisconsin American Family
Children’s Hospital, Madison, Wisconsin; Department of Pediatrics, Cardinal
Glennon Children’s Medical Center, St. Louis, Missouri; and Colorado State
University, Ft. Collins, Colorado
To assess the impact of hGH therapy begun early in life on the natural
history of PWS, comparisons were made of height, body composition, and strength
in similar-age children with PWS who had never been treated with hGH with those
with PWS treated with hGH for 6 years.
Forty-eight children with PWS were studied: 21 subjects aged 6–9 years who
had been treated with hGH for 6 years beginning at 4–32 months were compared
with 27 children aged 5-9 years prior to treatment with hGH. Percent body fat,
lean body mass, carbohydrate/lipid metabolism, and motor strength were compared.
Conclusions: hGH treatment in children with PWS, begun prior to 2 years of
age, improves body composition, motor function, height, and lipid profiles. The
magnitude of these effects suggests that long-term hGH therapy favorably alters
the natural history of PWS to an extent that exceeds risks and justifies
consideration for initiation during infancy.
[Note: For more detailed information, see The Journal of Clinical
Endocrinology & Metabolism Vol. 95, No. 3 1131-1136, 2010]
edited:
02/09/2012
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